Di-fluoro azepane HBV capsid assembly modulators

Lindsey G. DeRatt,Bart Stoops,Paul Shaffer,Angela M. Lam,Christine Espiritu,Robert Vogel,Vincent Lau,Osvaldo A. Flores,Scott D. Kuduk

Bioorganic & Medicinal Chemistry Letters（2023）

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摘要

The HBV core protein has multiple essential functions in the HBV life cycle to enable chronic HBV infection. Herein is described the evolution of an advanced series of di-fluoro azepane HBV capsid assembly modulators.

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di-fluoro

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