Deferoxamine ameliorates neurological dysfunction by inhibiting ferroptosis and neuroinflammation after traumatic brain injury

•TBI causes oxidative stress and neuroinflammation in brain tissue, which in turn causes ferroptosis.•DFO can reduce oxidative stress and iron death levels after TBI.•GSNO reduces TBI-induced neurodegeneration and aids in functional recovery.•DFO can reduce NF-kb pathway expression after TBI, which in turn reduces pyroptosis and attenuates neuroinflammation.