Curcumin-Incorporated Biomaterials: In silico and in vitro evaluation of biological potentials

•In experimental, understanding the pharmacokinetics and pharmacodynamics of curcumin and the interaction between curcumin and targets is intricate.•Integration of experimental and computational methods assists and enriches our interpretation of the experimental results.•Challenges in curcumin therapy, including its side effects, low bioavailability, and rapid metabolism, are carefully elaborated.•Computational methods can shed light onto the biological mechanism of curcumin and also predict the curcumin’s action against available diseases and decrease drug failure.•In-depth perspectives regarding the future utilization of curcumin in human health are provided.