An Aptamer-Mediated Base Editing Platform for Simultaneous Knock-in and Multiple Gene Knockout for Allogeneic CAR-T Cells Generation

Immacolata Porreca,Robert Blassberg,Jennifer Harbottle, Bronwyn Joubert,Olga Mielczarek,Jesse Stombaugh,Kevin Hemphill,Jonathan Sumner, Deividas Pazeraitis, Julia Liz Touza,Margherita Francescatto,Mike Firth,Tommaso Selmi,Juan Carlos Collantes,Zaklina Strezoska,Benjamin Taylor,Shengkan Jin,Ceri M. Wiggins,Anja van Brabant Smith,John J. Lambourne

MOLECULAR THERAPY（2024）

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关键词

base editing,gene editing,CRISPR,allogeneic cell therapy,multiple base editing,multiple gene knockout,transgene integration,knockin,knockout,advanced genome editing

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