ASF1B May Regulate the Tumor Microenvironment and Epithelial-mesenchymal Transition in Malignant Mesothelioma to Induce the Differentiation of Sarcomatoid Phenotype as a Prognosis Target

Abstract IntroductionMalignant mesothelioma (MM) is a rare malignant tumor with a poor survival. However, few markers are verified that related to sarcomatoid differentiation or further stratification of prognosis.MethodsWe analysis the significance of ASF1B expression in MM by analyzing the public dataset from TCGA, GEO and Oncomine database. Furthermore, we investigated the biological function of ASF1B in immune microenvironment and the effect of ASF1B in survival, gene ontology enrichment, GSEA enrichment and related microRNA.ResultsASF1B expression was significantly higher in MM by GEO data compared to normal lung tissue (p<0.0001). This study provides evidence that the increased expression of ASF1B is significantly associated with poor prognosis and inhibitory immune cell infiltration in patients with MM and highlight that ASF1B could be used as a novel predictive biomarker for the prognosis of MM which is related to the differentiation of sarcomatoid phenotype.ConclusionASF1B May Regulate the Tumor Microenvironment and Epithelial-mesenchymal Transition in Malignant Mesothelioma to Induce the Differentiation of Sarcomatoid Phenotype as a Prognosis Target. Further researches need to be conducted to figure out how exactly the ASF1B affect the microenvironment.