IVF in a Woman with Cogenital Hypofibrinogenemia ---Case Report

Abstract Background: Cogenital hypofibrinogenemia is a rare inherited coagulation disorder and the complications of this disease are bleeding and thrombosis. Pregnant women with cogenital hypofibrinogenemia are at high risk of abortion and placental abruption. This report is intended as a reference for IVF in women with congenital hypofibrinogenemia.Case presentation: A 31-year-old woman with cogenital hypofibrinogenemia and secondary sterility who was treated with IVF and cryoprecipitate. After ten months she delivered a live boy.Conclusion: During IVF,elevated HCG increases the risk of thrombogenesis. So we didn’t get as much fibrinogen supplementation as the literature suggested when we did FRT.