Optimal Oxygen Saturation Targets in Patients with Sepsis- Associated Encephalopathy: A Cohort Study from the MIMIC-IV Database

Abstract Objectives: Patients with sepsis-associated encephalopathy (SAE) in the intensive care unit (ICU) are treated with supplemental oxygen. However, few studies have investigated the impact of oxygenation status on the patient with SAE, and the optimal oxygenation status target remains unclear. We aimed to investigate the relationship between optimal oxygenation status and patients with SAE.Methods: This study is a retrospective cohort study. Patients were diagnosed with sepsis3.0 at the first ICU admission between 2008 and 2019 from Medical Information Mart for Intensive Care IV (MIMIC IV). We use generalized additive models to estimate the optimal oxygen saturation targets in patients with SAE. Multivariate logistic analysis to further confirm it. Measurements and Main Results: A total of 6714 patients with SAE were included. The incidence of patients with SAE was 66.8%, and hospital mortality was 7.9%. SpO2≤92% was the independent risk factor of incidence in patients with SAE. The optimal range of SpO2 was 93%–97%, which can reduce the incidence of patients with SAE. The optimal range of SpO2 was 92%–96%, reducing the hospital mortality of patients with SAE.Conclusions: The optimal range of SpO2 was 93%–96% reduce the hospital mortality and incidence of patients with SAE. SAE patients need conservative oxygen therapy