An integrated multi-omics study to identify dynamic molecular alterations associated with acute brain injury

Abstract In response to acute brain injury (ABI) threats, neuroimmune cells rapidly transition from a quiescent into an activated state, but the dynamic molecular alterations are partially understood. Here, we integrated the dynamics of multi-omics datasets in four ABI mice models. Transcriptomics revealed diversification of thermogenesis, synaptic, and neuroinflammatory genes for ABI at the early phase (12H). Transcriptomics and proteomics combined analysis singled out 15 co-variation risk genes for ABIs. Besides, lipid metabolite alteration reflected a discrepancy between permanent ischemic brain injuries and transient ischemic brain injuries at the middle phase (24H). Together, our data elucidate a potential therapeutic resource for ABIs.