Effect of High-intensity Interval Training on patients with Type 2 Diabetes Mellitus: An Overview of Systematic Reviews

Abstract BackgroundType 2 Diabetes Mellitus (T2DM) is a serious disease. The intervention of High Intensity Interval Training (HIIT) on T2DM is widely concerned but controversial, which also exists in the current Systematic Reviews/Meta-Analysis (SRs/MAs). The objective of this study is to evaluate the methodology, evidence and reporting quality of SRs/MAs of the effects of HIIT on patients with T2DM. MethodsPubMed, Embase, Cochrane Library, Web of Science, CNKI, WanFang Data, SinoMed and VIP were searched. A MeaSurement Tool to Assess Systemic Reviews 2 （AMSTAR2）, Risk of Bias in Systematic Review（ROBIS）,Grading of Recommendations Assessment, Development and Evaluation（GRADE）were used to evaluate the included studies.ResultsSix SRs/MAs studies were included, with 79 outcomes from 21 original studies. Methodological quality of AMSTAR2 evaluation was extremely low. ROBIS evaluation showed high risk of bias. There are 39 outcomes of 3 included SRs/MAs used GRADE, of which 29 items are low, 8 items are very low, and 2 items are intermediate quality. Low quality and very low quality evidence bodies account for 95% of the total.ConclusionsSRs/MAs on the effect of HIIT intervention on patients with T2DM included a small number of original studies and the overlapping feature is obvious, outcomes are diverse and overlapping, and there is a lack of key and ending outcomes; From original study, outcomes to system reviews, quality of evaluation is low. Evidence from a large samples, long periods, better protocols, and reflecting ending outcomes and critical outcomes are needed to promote the application of HIIT in T2DM.