Low-intensity, Long-wavelength Red Light Slows the Progression of Myopia in Children: an Eastern China-based Cohort

Abstract Myopia is prevalent worldwide, particularly in East and Southeast Asia. Recent studies have suggested that the spectral composition of ambient lighting influences refractive development, especially in humans. We aimed to determine the effect of 650-nm single-wavelength red light on the inhibition of myopia progression in children. In this retrospective cohort study, 105 myopic children (spherical equivalent refractive error [SER], -6.75 to -1.00 dioptres (D)) aged from 4 to 14 years old were retrospectively reviewed. Subjects were treated with 650-nm, low-intensity, single-wavelength red light twice a day for 3 minutes each session, with at least a 4-hour interval between sessions. IOL Master was utilized to measure the axial length (AL) and corneal curvature. Choroidal images were assessed using enhanced depth imaging optical coherence tomography (EDI-OCT), and the luminal area (LA) and stromal area were converted to binary images by the Niblack method. At baseline, the mean SER was -3.09 ± 1.74 D and -2.87 ± 1.89 D at 9 months, and significant changes occurred over time (P = 0.019). The AL increased by -0.06 ± 0.19 mm for 9 months (0.21 ± 0.15 mm pretreatment; P＜0.001). The subfoveal choroidal thickness (SFChT) had changed by 45.32 ± 30.88 μm at the 9-month examination (P＜0.001). Repetitive exposure to 650-nm, low-intensity, single-wavelength red light effectively slowed the progression of myopia and reduced axial growth after short treatment durations. These results require further validation in a longitudinal study, as well as further research in animal models.