Mechanistic insights into the beneficial effects of curcumin on insulin resistance: Opportunities and challenges

•T2DM is considered a debilitating metabolic disorder characterized by insulin resistance.•Evidence suggests potential beneficial effects of curcumin on insulin resistance.•Curcumin causes upregulation of PPARγ, whose activation regulates insulin sensitivity.•Curcumin suppresses Notch‑1 signaling to improve insulin resistance.•Curcumin improves the levels of circulating irisin and adiponectin to combat insulin resistance.