Furanocoumarin Notopterol: Inhibition of Hepatocellular Carcinogenesis through Suppression of Cancer Stemness Signaling and Induction of Oxidative Stress-Associated Cell Death.

Ting-Yun Huang,Ching-Kuo Yang,Ming-Yao Chen,Vijesh Kumar Yadav,Iat-Hang Fong,Chi-Tai Yeh,Yih-Giun Cherng

Nutrients（2023）

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摘要

In summary, we demonstrated for the first time that NOT exhibits strong anticancer activity via the suppression of cancer stemness, enhanced endoplasmic reticulum stress and increased oxidative stress thus projecting NOT as a potentially effective therapeutic agent against HCC.

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关键词

hepatocellular carcinoma,HCC,notopterol,anticancer treatment,oxidative stress,endoplasmic reticulum stress,cancer stemness

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