Extracellular vesicles derived from hypoxic HTR-8/SVneo trophoblast inhibit endothelial cell functions through the miR-150-3p /CHPF pathway.

Menghan Sha, Shunran Zhang,Rajluxmee Beejadhursing,Yanan Sun,Yu Qin,Suhua Chen,Wei Li

Placenta（2023）

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摘要

Our findings indicate that extracellular vesicles miR-150-3p derived from hypoxic trophoblasts inhibits endothelial cells proliferation, migration, and angiogenesis by modulating CHPF, illuminating a novel mechanism of hypoxic trophoblasts regulation of endothelial cells and their potential role in PE pathogenesis.

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关键词

Extracellular vesicle,Endothelial cell,miR-150-3p

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