Enzymeless Electrochemical Glucose Sensors Based on Metal-Organic Framework Materials: Current Developments and Progresses

Electrochemical glucose sensors play a crucial role in medicine, bioscience, food science, and agricultural science. Metal-organic frameworks possess exceptional properties, such as large specific surface area, high porosity, tunable pore structure, high catalytic activity, open metal active sites, and structural diversity. The catalytic activity of metal-organic frameworks enables electrocatalytic oxidation of glucose without the need for enzymes. Consequently, enzymeless electrochemical glucose sensors based on metal-organic framework materials have gained much attention and have been extensively studied for glucose detection. This mini-review provides an overview of the development and progress of enzymeless electrochemical glucose detection based on metal-organic framework material-modified electrodes, including doping materials, sensitivity, detection limit, and fast response capability. With the advancement of this technology, enzymeless electrochemical glucose sensors can continuously and stably detect glucose and can be utilized in various fields, such as wearable devices.