Efficacy and safety of maintenance therapy with pamiparib versus placebo for advanced gastric cancer responding to first-line platinum-based chemotherapy: Phase 2 study results.

Fortunato Ciardiello,Yung-Jue Bang,Andrés Cervantes,Mikhail Dvorkin,Charles D Lopez,Jean-Philippe Metges, Antonio Sánchez Ruiz,Mariona Calvo,Andrew H Strickland,George Kannourakis,Kei Muro,Hisato Kawakami,Jia Wei,Christophe Borg, Zhaoyin Zhu, Neal Gupta, Robert J Pelham,Lin Shen

Cancer medicine（2023）

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摘要

Maintenance pamiparib did not meet statistical significance for superiority versus placebo for PFS, but was well tolerated with few treatment discontinuations; no unexpected safety signals were identified.

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关键词

clinical trial,gastric cancer,maintenance,phase 2,poly(ADP-ribose) polymerase inhibitors

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