The SINTART 1 study. A phase II non-randomised controlled trial of induction chemotherapy, surgery, photon-, proton- and carbon ion-based radiotherapy integration in patients with locally advanced resectable sinonasal tumours.

Carlo Resteghini,Paolo Castelnuovo,Piero Nicolai,Ester Orlandi,Paolo Bossi,Barbara Vischioni,Alberto Schreiber,Simone Gambazza,Nicola Alessandro Iacovelli,Paolo Battaglia,Marco Guzzo,Mario Turri-Zanoni,Davide Mattavelli,Nadia Facchinetti,Giuseppina Calareso,Marco Ravanelli,Carla Facco,Tiziana Tartaro,Lisa Licitra

European journal of cancer (Oxford, England : 1990)（2023）

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摘要

Treatment of advanced sinonasal cancer with histology-driven ICT followed by (CT)RT in responsive patients was feasible. Overall, these findings suggest a possible role of ICT as the primary approach in newly diagnosed, resectable sinonasal tumours-especially SNUC-to select patients with favourable prognosis. Histology heterogeneity limits generalisation of trial results.

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关键词

Resectable sinonasal tumours,Multimodal therapy,Heavy ion therapy,Endoscopic surgery,Induction chemotherapy

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