Promoter hypermethylation of SFRP1 as a prognostic and potentially predictive blood-based biomarker in patients with localized pancreatic ductal adenocarcinoma.

Benjamin Emil Stubbe,Anders Christian Larsen,Poul Henning Madsen,Henrik Bygum Krarup,Inge Søkilde Pedersen,Søren Lundbye-Christensen,Carsten Palnæs Hansen,Jane Preuss Hasselby,Astrid Zedlitz Johansen,Ole Thorlacius-Ussing,Julia Sidenius Johansen,Stine Dam Henriksen

Frontiers in oncology（2023）

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摘要

Results could indicate that the poor prognosis may be caused by reduced benefit from adjuvant chemotherapy. SFRP1 may help guide the clinician and be a possible target for epigenetically modifying drugs.

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关键词

biomarker,pancreatic cancer,survival,epigenetic,DNA methylation,personalized therapy,blood-based,cfDNA

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