Regulation of enteric nervous system via sacral nerve stimulation in opioid-induced constipated rats.

Liyun Wang,Payam Gharibani,Yi Yang,Yu Guo,Jieyun Yin

FRONTIERS IN NEUROSCIENCE（2023）

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摘要

SNS with appropriate parameters improves opioid-induced constipation and reversed the detrimental effects of Loperamide on enteric neurons possibly via the GDNF-PI3K/Akt pathway.GRAPHICAL ABSTRACT.

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关键词

sacral nerve stimulation,opioid-induced constipation,autonomic functions,enteric neurons,neuromodulation

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