Iridium-Catalyzed Site- and Enantioselective C(sp2)-H Borylation of Benzhydryl Ethers: Enantioselectivity Amplification by Kinetic Resolution Relay
CHINESE JOURNAL OF CHEMISTRY(2023)
摘要
Comprehensive SummaryWe herein report a simple ether-directed iridium-catalyzed site- and enantioselective C(sp(2))-H borylation of benzhydryl ethers for the first time. Various chiral benzhydryl ethers were obtained with high enantioselectivities in the presence of a tailor-made chiral bidentate boryl ligand. We found that the kinetic resolution relay significantly amplified the enantioselectivity. The synthetic utility of the current method was demonstrated by gram-scale C-H borylation and C-B bond transformations.
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关键词
Asymmetric catalysis,Benzhydryl ethers,C-H activation,Enantioselectivity,Kinetic resolution
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