Uterus-Derived Decellularized Extracellular Matrix-Mediated Endometrial Regeneration and Fertility Enhancement
ADVANCED FUNCTIONAL MATERIALS(2023)
摘要
Tissue-specific decellularized extracellular matrix recapitulates the complexity of natural ECMs, creating an organ-specific microenvironment based on its intrinsic characteristics. Here, hydrogels containing uterus-derived decellularized extracellular matrix (UdECMs) from the endometrium-specific layer or the entire uterus are developed. UdECMs serve as effective organ-specific biomaterials, displaying that intrauterine UdECM administration induces endometrial regeneration and fertility enhancement. Moreover, UdECM administration alters the profile of natural killer cell subpopulations to exhibit more mature and less cytotoxic features, providing a favorable uterine environment for successful implantation and decidualization. Interestingly, insulin-like growth factor 1 and insulin-like growth factor-binding protein 3 as key regulatory factors that contribute to UdECM-mediated endometrial regeneration are discovered. Furthermore, ex vivo culture of human uterine tissues reveals that UdECMs of different origins exhibit distinct therapeutic effects based on the endometrial conditions of patients, suggesting their uses as a therapeutic intervention providing personalized regenerative medicine for infertile patients with a poor uterine environment.
更多查看译文
关键词
uterus‐derived,fertility,regeneration
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要