Design, Synthesis, and Insecticidal Activity of Mesoionic Pyrido[1,2- a ]pyrimidinone Containing Isoxazole/Isoxazoline Moiety as a Potential Insecticide.

Bean aphid () resistance to commonly used insecticides has made controlling these pests increasingly difficult. In this study, we introduced isoxazole and isoxazoline, which possess insecticidal activity, into pyrido[1,2-]pyrimidinone through a scaffold hopping strategy. We designed and synthesized a series of novel mesoionic compounds that exhibited a range of insecticidal activities against . The LC values of compounds and were 0.73 and 0.88 μg/mL, respectively, better than triflumezopyrim (LC = 2.43 μg/mL). Proteomics and molecular docking analyses showed that might influence the nervous system by interacting with neuronal nicotinic acetylcholine receptors (nAChRs). This research offers a new approach to the advancement of novel mesoionic insecticides.