A New Flavonoid Glycoside and Other Constituents from Sedum sarmentosum with Anti-Inflammatory Activity

One new flavonol glycoside ( 1 ), together with one known flavonol glycoside ( 2 ) and 16 known megastigmanes ( 3 – 18 ) were isolated from the whole plant of Sedum sarmentosum Bunge. Their structures were established by spectroscopic data (1D, 2D NMR, and HR-ESI-MS) and comparison with the literature. Among them, compounds 8 and 10 – 12 were reported from the Crassulaceae family for the first time. Anti-inflammatory effects of the isolated compounds were evaluated in terms of inhibition of NO, TNF- α , and IL-6 production in lipopolysaccharide-stimulated RAW 264.7 cells. Compounds 8 and 16 could inhibit NO production with IC 50 values of 47.93 ± 3.43 μM and 47.11 ± 3.63 μM. Compounds 4 and 6 showed an inhibitory effect on IL-6 production with IC 50 values of 34.37 ± 4.84 μM and 38.26 ± 3.32 μM.