The critical role of pancreatic stone protein/regenerating protein in sepsis-related multiorgan failure.

Ping Hu,Yuan Hua Lu,Wei Deng,Qi Li,Ning Zhao,Qiang Shao, Ling Wu,Xu Zhen Wang,Ke Jian Qian,Fen Liu

Frontiers in medicine（2023）

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摘要

Patient prognosis and progression to MODS can be visualized by monitoring PSP/Reg levels upon ICU admission. Additionally, PSP/Reg administration in animal models exacerbates the inflammatory response and severity of multiorgan damage, which may be accomplished by promoting the inflammatory state of neutrophils.

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sepsis,neutrophils,infiltration,pancreatic stone protein,multiple organ dysfunction syndrome

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