High-power Terahertz Waves for a Recycle System of Amyloid Fibrils
Research Square (Research Square)(2021)
摘要
Abstract Recycling of persistent materials is one of most important subjects to be addressed towards the sustainable society. Amyloid fibril is such a tough biomaterial that can be designed for various industrial applications, and it is usually difficult to dissociate the once made fibrous conformation due to the cross β-sheet stacks. We propose here a unique but versatile approach to handle the fibril formation by using two-kinds of high-power terahertz waves. Lysozyme and β2-microglobulin peptide fragment were employed as model samples, and those fibrils were clearly disaggregated accompanied by decrease of β-sheets and increase of α-helices by the irradiation of 5.3 THz free electron laser tuned to 56 μm, as shown by infrared (IR) microscopy and scanning-electron microscopy (SEM). In contrast, those fibrous conformations were reversely self-associated by the irradiation of 0.42 THz wave tuned to 720 μm from gyrotron, as shown by optical and IR microscopies, SEM, and small-angle X-ray scattering. The overall reaction is performed at room temperature within 30 min without external heating and high-pressures. Therefore, amyloid fibrils can be dissociated and associated under the proper far-infrared radiation conditions, which inspires a sustainable recycling system of fibrous biomaterials.
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关键词
amyloid fibrils,terahertz,recycle system,high-power
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