Non-invasive detection of total bilirubin based on multi-wavelength PPG signal.

•Noninvasive detection of human total bilirubin concentration based on multi-wavelength PPG signal.•Propose a method to screen sample spectra based on the degree of PPG deviation.•Propose a multi-component concentration distribution selection sample set method to achieve analysis in complex solutions.•The detection error of the final model bilirubin is only 9.3%.