Personalized bacteriophage therapy to treat pandrug-resistant spinal P. aeruginosa infection

Tristan FERRY,Camille KOLENDA,Frederic LAURENT,Gilles LEBOUCHER, Maya Merabischvilli, Sarah DJEBARA,Claude-Alexandre GUSTAVE,Thomas Perpoint, Cédric Barrey,Jean-Paul Pirnay,Gregory Resch

Research Square (Research Square)（2022）

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摘要

Abstract A pandrug-resistant P. aeruginosa spinal abscess was treated with surgery and personalized phage therapy that was added to cefiderocol and colistin. After a 2-stage approach, despite bacterial persistence with expression of small colony variants, the patient cured with local and intravenous injections of purified bacteriophages as part of the treatment.

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关键词

personalized bacteriophage therapy,infection,pandrug-resistant

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