Rare event of NTRK3 rearrangement and amplification in esophageal squamous cell carcinoma

Abstract This study observed the rearrangement and amplification of NTRK3 in a large sample, providing a basis for the potential treatment of NTRK in esophageal cancer. The tissue microarray of 478 cases was detected by fluorescence in situ hybridization (FISH) assay. Results of this study show that both NTRK3 gene rearrangement and copy number variation are rare events in ESCC. Gene rearrangement and copy number changes have little influence on the prognosis.Except when gene copy number was greater than or equal to 4, patients with stage I+II showed a trend of poor prognosis (P=0.120; OS, P=0.095). Conclusion NTRK3 gene rearrangement and gene copy number variation are rare in esophageal cancer, and gene rearrangement does not affect prognosis, while the number of gene copies was 4 as the threshold, there was a tendency of poor prognosis.