The Correlation Between Homocysteine, Blood Coagulation and the Breast Cancer Risk and Clinicopathological Characters: A Case Control Study

Abstract Purpose To investigate the correlation between homocysteine, coagulation function indexes and breast cancer risk and clinicopathological characteristics. Methods From January 2018 to December 2018, coagulation function test results and clinicopathological data from 369 female breast cancer patients were collected. 183 women with benign breast disease were selected as the control group. Results: The levels of HCY, Fbg and D-D in the peripheral blood of breast cancer patients were higher than those of the control group (P < 0.05); PT, AT-Ⅲ, PC, F-VIII, and α2-AP were lower (P < 0.05). Concentrating on different menstruation status, serum levels of AT-Ⅲ, PC and α2-AP in menopausal patients were lower than those in the control group (P < 0.05); HCY, Fbg and D-D in postmenopausal patients were higher than those in the control group (P < 0.05), while the PT, F-VIII and α2-AP were lower than those of the control group (P < 0.05). The levels of HCY, Fbg, AT-Ⅲ, PC, α2-AP, FDP, and D-D are higher in T2-T4 breast cancer patients than in Tis-T1 breast cancer patients, PT and ATPP levels are higher in Tis-T1 breast cancer patients; Fbg, AT-Ⅲ, α2-AP levels are increased in breast cancer patients with lymph node metastasis. Among premenopausal breast cancer patients, HCY, Fbg, and D-D levels were increased in patients with T2-T4 stage (P < 0.05); Fbg, AT-Ⅲ, and α2-AP levels were increased in patients with lymph node metastasis (P < 0.05). In postmenopausal patients, the levels of PT (SEC), AT-Ⅲ, PC, α2-AP, FDP, and D-D in the T2-T4 stage are higher than those in the Tis-T1 stage, and the levels of AT-Ⅲ and α2-AP in the lymph node metastasis increased in the number of patients (P < 0.05). The abnormal rate of HCY and PT in the triple-negative patients was higher than that in the Luminal A + B group and the HER-2 overexpression group. The abnormal rate of Fbg in the HER-2 overexpression patients was higher than that in the Luminal A + B group and the triple-negative group (P < 0.05). Conclusions Homocysteine and abnormal blood coagulation are related to the risk of breast cancer, and tumor size, lymph node metastasis and molecular typing in breast cancer patients.