Dopaminergic signaling is linked to neurodevelopmental deficits in autism spectrum disorder (ASD)

Abstract Neural circuit defects are a prominent feature of autism spectrum disorder (ASD). However, the specific defects in neural circuits and the resulting pathogenesis are not well understood. We conducted a systematic analysis of two ASD datasets and found alterations in multiple neurodevelopmental pathways and in dopaminergic signaling pathways. Interestingly, the dopaminergic signaling pathways are associated with neurodevelopmental pathways in patients with ASD. We also discovered that disruption of the dopaminergic system leads to neural circuit formation defects. Our study suggests a new therapeutic target for ASD.