Single Center Experience of pulmonary thromboendarterectomy for Chronic Thromboembolic Pulmonary Hypertension: result from the TUMS-CTEPH registry

Abstract Introduction: Pulmonary thromboendarterectomy remains the preferred and potentially curative option for patients with chronic thromboembolic pulmonary hypertension (CTEPH). The objective of this study was to report the result of pulmonary thromboendarterectomy (PEA) for chronic thromboembolic pulmonary hypertension (CTEPH) in a single tertiary center.Method: This study presents a analysis of CTEPH patients who underwent PEA enrolled in the Tabriz University of Medical sciences (TUMS-CTEPH) registry. This registry enrolled patients with CTEPH. The main outcome measures were Functional New York Heart Association [NYHA] class, 6‑Minute Walk Distance, hemodynamic measures in right heart catheterization, morbidity and mortality. Results: Here we reported 42 CTEPH patients who underwent PEA between January 2016 to October 2020. There were significant improvement in function class (2.6+-0.5 vs. 1.1+-0.34, p=0.00), mean PAP (47.1+-13 mmHg vs. post 27.9+-8 mmHg, p=0.000), cardiac output ( 4.3+-1.06 l/min vs. post 5.9+-1.2, p= 0.000 ), and pulmonary vascular resistance (709.4+-297.5 dynes • sec 1 • cm 5 vs. 214+-77 dynes • sec 1 • cm 5, p= 0.000 ). Fifteen patients (35%) developed complications. The most common complication was reperfusion injury in 10 (%23) patients. There was 4% post-surgical mortality during hospital admission and one year follow-up. Conclusion: In this first single center report of PEA from Iran, post PEA and one year survival is comparable to that in other contemporary CTEPH centers. PEA can be performed safe with low mortality. Greater awareness of PEA and patients access to experienced CTEPH centers are important aim.