A meta-analysis of the diagnostic accuracy of type Ⅳ collagen 7S for the staging of liver fibrosis in NAFLD

Abstract We aimed to evaluate the diagnostic accuracy of the measurement of type Ⅳ collagen 7S (T4C7S) concentration for the staging of liver fibrosis in patients with nonalcoholic fatty liver disease (NAFLD). A systematic literature search was performed using the PubMed, Cochrane Library, and Web of Science Core Collection databases for studies of the accuracy of T4C7S for the staging of fibrosis using Fibrosis stage (F) 0–4 in patients with NAFLD diagnosed by liver biopsy. Nine articles describing 1,475 participants with NAFLD were included. For fibrosis ≥ F1, with n = 849, summary estimates of sensitivity of 0.79, specificity of 0.69, and area under the curve (AUC) of 0.80 were obtained using a median T7C4S cut-off value of 4.6. For fibrosis ≥ F2, with n = 1,090, summary estimates of sensitivity of 0.78, specificity of 0.78, and AUC of 0.84 were obtained using a median cut-off value of 4.9. For fibrosis ≥ F3, with n = 1,311 participants and a median cut-off value of 5.4, a pooled sensitivity of 0.82, specificity of 0.81, and AUC of 0.83 were obtained. For fibrosis ≥ F4, with n = 753 and a median cut-off value of 6.6, a pooled sensitivity of 0.85, specificity of 0.81, and AUC of 0.85 were obtained. T4C7S concentration was found to be an accurate method of staging liver fibrosis in patients with NAFLD.