HLA haplotypes and differential regional mortality caused by COVID-19 in Brazil: an ecological study based on a large bone marrow donor bank dataset

Juliano André Boquett,Fernanda Sales Luiz Vianna,Nelson Jurandi Rosa Fagundes,Lucas Schroeder,Marcia Barbian,Marcelo Zagonel-Oliveira,Tiago Finger Andreis,Luis Cristóvão de Moraes Sobrino Pôrto,José Artur Bogo Chies,Lavinia Schuler-Faccini,Patricia Ashton-Prolla,CLÉVIA ROSSET

Research Square (Research Square)（2022）

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摘要

Abstract The human leukocyte antigen (HLA) genotype may influence in immune responses during the course of coronavirus disease 2019 (COVID-19). In this ecological study, we collected HLA genotypes from 4,148,713 Brazilian individuals and compared to COVID-19 data. We found a positive significant correlation between the HLA-A*01~B*08~DRB1*03 haplotype and COVID-19 mortality rate.

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hla haplotypes,differential regional mortality

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