Expression and prognosis of m6A methylation factor in HNSCC

Abstract In this study, We comprehensively analyzed 20 genes from The Cancer Genome Atlas(TCGA) HNSCC database (YTHDF1, FTO, YTHDF2, YTHDF3, HNRNPA2B1, METTL14, METTL3, IGF2BP1, HNRNPC, IGF2BP2, RBMX, IGF2BP3, YTHDC1, YTHDC2, RBM15, RBM15B, VIRMA, ZC3H13, WTAP, ALKBH5) to predict whether there is an impact on the prognosis of patients with HNSCC. The importance of 20 m6A regulators such as VIRMA in the pathogenesis of HNSCC was emphasized. These findings will provide a therapeutic approach and new research direction for the expression of m6A in patients with HNSCC and its prognosis.