Sigma-1R overexpression in PVN deteriorated heart injury by upregulating sympathetic nerve tone

Rui Wu, tingting Yu, xianglin Chen,Tian Yu, Hong Zhang,Haiying Wang,Zhi Xiao, Ke Li,Chi Cheng

Research Square (Research Square)(2022)

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摘要
Abstract Sympathetic nerve tone chronically maintains at high level is harmful to heart. However, little is known how to control sympathetic nerve tone. It has been reported that sigma-1 receptors played a multi-functional role in central nervous system diseases, but little is known about the function for adjusting sympathetic tone of sigma-1 receptors within paraventricular nucleus (PVN). We examined the effects of sigma-1 receptor within PVN on heart by two models: cardiopulmonary bypass model (CPB) and cirrhotic cardiomyopathy (CCM) induced by bile duct ligation. It was found that sigma-1R overexpression in PVN aggravated brain inflammation and increased sympathetic output with more serious heart change. Right stellate ganglion block alleviated the cardiac damage caused by Sigma-1R overexpression in PVN during CPB. In CCM model, it was found that overexpression of sigma-1 receptor in PVN promoted occurrence of fibrosis and senescence in heart. These findings suggest that sigma-1R overexpression in PVN deteriorate heart injury by upregulating sympathetic nerve tone.
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关键词
sympathetic nerve tone,heart injury,pvn
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