Synaptic density in aging mice measured by [18F]SynVesT-1 PET

Mengfei Xiong,Sahar Roshanbin,Dag Sehlin,Hanne D. Hansen,Gitte M. Knudsen,Johanna Rokka,Jonas Eriksson,Stina Syvänen

NeuroImage（2023）

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摘要

•[18F]SynVesT-1 PET shows synaptic density to be stable during aging, ….•…except at a very old age when a small decrease is seen in healthy C57BL/6 J mice.•Acquisition time of 60 min together with 1TCM gave robust pharmacokinetic parameter estimates.

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关键词

Synaptic density,Aging,Positron emission tomography (PET),Mice

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