Modeling Alzheimer's disease related phenotypes in the Ts65Dn mouse: impact of age on Aβ, Tau, pTau, NfL, and behavior.

Cassia Overk, Emma Fiorini,Chiara Babolin,Marija Vukicevic,Catherine Morici,Rime Madani,Valerie Eligert,Marie Kosco-Vilbois,Amanda Roberts,Ann Becker,Andrea Pfeifer,William C Mobley

Frontiers in Neuroscience（2023）

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摘要

These data have implications for planning future experiments aimed at preventing disease-related phenotypes and biomarkers. Interventions should be planned to address specific manifestations using treatments and treatment durations adequate to engage targets to prevent the emergence of phenotypes.

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关键词

DS-AD,animal model,age,Down syndrome,Alzheimer’s disease,tau

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