Hemophagocytic lymphohistiocytosis/macrophage activation syndrome: a case series

Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening hematologic disorder occurring more commonly in children, but there are reported cases in adults as well. It is classified as a primary HLH or secondary HLH, which can occur due to autoimmune diseases, infections, and malignancies. Secondary HLH is a challenge for physicians concerning diagnosis and management. In this case series, we report two patients of HLH diagnosed between August 2018 and August 2019 at Shaukat Khanum Memorial Cancer Hospital & Research Centre Lahore Pakistan, which were triggered by different underlying conditions like autoimmune diseases and malignancies or a combination of both.