A phase 2 randomized controlled dose-ranging trial of recombinant pertussis booster vaccines containing genetically inactivated pertussis toxin in pregnant women

Thanyawee Puthanakit,Kulkanya Chokephaibulkit,Surasith Chaithongwongwatthana,Niranjan Bhat,Yuxiao Tang,Suvaporn Anugulruengkitt,Chenchit Chayachinda,Sanitra Anuwutnavin,Keswadee Lapphra,Supattra Rungmaitree,Monta Tawan,Indah Andi-Lolo,Renee Holt,Librada Fortuna, Chawanee Kerdsomboon, Vilasinee Yuwaree,Souad Mansouri,Pham Hong Thai,Bruce L. Innis

SSRN Electronic Journal（2023）

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摘要

•Recombinant acellular pertussis vaccine is safe and immunogenic in pregnant women.•Vaccine formulations containing PTgen were non-inferior to comparator vaccine.•Low-dose ap1gen is good alternative for pregnant women when DT and TT are not needed.

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关键词

Pertussis,Genetically inactivated,Maternal immunization,Recombinant pertussis vaccine,Safety,Immunogenicity

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