HLA-II-Associated HIV-1 Adaptation Decreases CD4 ⁺ T-Cell Responses in HIV-1 Vaccine Recipients

Jacob K. Files,Sarah Sterrett, Sebastian Henostroza,Christopher Fucile,Kevin Maroney,Tim Fram,Simon Mallal,Spyros Kalams,Jonathan Carlson,Alexander Rosenberg,Nathan Erdmann,Anju Bansal,Paul A. Goepfert

Journal of Virology（2022）

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摘要

Despite decades of research, an effective HIV-1 vaccine remains elusive. Vaccine strategies leading to the generation of broadly neutralizing antibodies are likely needed to provide the best opportunity of generating a protective immune response against HIV-1.

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cd4,hla-ii-associated,t-cell

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HLA-II-Associated HIV-1 Adaptation Decreases CD4 + T-Cell Responses in HIV-1 Vaccine Recipients

HLA-II-Associated HIV-1 Adaptation Decreases CD4 ⁺ T-Cell Responses in HIV-1 Vaccine Recipients