Cidofovir for treating complicated monkeypox in a man with severe acquired immunodeficiency

Abstract On July 23, the World Health Organization (WHO) declared monkeypox (MPX) a global health emergency of international concern given its rapid spreading. So far, most current MPX outbreaks have involved young men who have sex with men (MSM), although with overall mild, self-limiting clinical manifestations. We aim to describe the case of a young MSM, HIV positive, whose status of utter immune suppression probably contributed to worsen the clinical course of MPX disease, thus requiring hospitalization and antiviral treatment. He was effectively treated with Cidofovir that may be a valuable component of a multi-faceted management of severe MPX.