Ester-stabilized phosphorus ylides as protonophores on bilayer lipid membranes, mitochondria and chloroplasts

Roman S. Kirsanov,Ljudmila S. Khailova,Tatyana I. Rokitskaya,Iliuza R. Iaubasarova,Pavel A. Nazarov,Alisa A. Panteleeva,Konstantin G. Lyamzaev,Lyudmila B. Popova,Galina A. Korshunova,Elena A. Kotova,Yuri N. Antonenko

Bioelectrochemistry（2023）

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摘要

•(Carboxymethyl)triphenylphosphonium alkyl esters CMTPP-Cn (n = 8–14) were studied.•Due to acidic CH bond between P and ester group these TPP salts are ylide precursors.•CMTPP-C10 induced proton-selective current through planar bilayer lipid membrane.•CMTPP-Cn uncoupled rat liver mitochondria collapsing their membrane potential.•CMTPP-C12 caused dissipation of pH gradient on chloroplast membranes.

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关键词

bilayer lipid membranes,protonophores,phosphorus,mitochondria,ester-stabilized

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