Research progress on the mechanism of interleukin-1β on epiphyseal plate chondrocytes

Abstract Epiphyses plate injury is one of the common problems in pediatric orthopedic surgeons. Interleukin-1β(IL-1β)-mediated inflammatory response is a major concern after clinical treatment of fractures and is bivalent in the growth and development of the epiphyses plate. As an extremely important inflammatory factor, IL-1β participates in the pathological development of a variety of bone and joint diseases by deeply affecting the molecular transcription level of chondrocytes and endocrine metabolism, and currently, there are few studies on epiphyses plate chondrocytes. Therefore, this review aims to illustrate the mechanism of IL-1β on chondrocytes and epiphyses plate chondrocytes, to shed light on theoretical grounds for clinical treatment and profound research of children epiphyses plate injury in the future.