AgSbF₆-catalyzed C3 aza-Friedel–Crafts alkylation of N,O-acetals with indoles for the synthesis of N-α indole substituted pyrrolidine and piperidine derivatives

Yu Zhang,Zi-Juan Yi,Ai-Mei Yang,Jia-Ming Guo,Xin Li,Bang-Guo Wei

Organic & Biomolecular Chemistry（2023）

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摘要

An efficient approach to access chiral N-α indole substituted pyrrolidine and piperidine skeletons has been developed through a AgSbF6-catalyzed N-α aza-Friedel–Crafts alkylation of N,O-acetals 6a, 6b, 9, and 11a–11d with indoles.

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piperidine derivatives,indoles,indoles,synthesis,<i>aza</i>-friedel–crafts alkylation

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AgSbF6-catalyzed C3 aza-Friedel–Crafts alkylation of N,O-acetals with indoles for the synthesis of N-α indole substituted pyrrolidine and piperidine derivatives

AgSbF₆-catalyzed C3 aza-Friedel–Crafts alkylation of N,O-acetals with indoles for the synthesis of N-α indole substituted pyrrolidine and piperidine derivatives