Small Activating RNA Modulation of the G Protein‐Coupled Receptor for Cancer Treatment (Adv. Sci. 26/2022)

Small Activating RNA Modulation In article number 2200562, Ling Peng, Leo Tsz On Lee, and co-workers, report for the first time that small activating RNA (saRNA) delivered by amphiphilic dendrimer can effectively modulate a G protein-coupled receptors (GPCR), Mas receptor, for cancer treatment. This project provides not only a new strategy for cancer therapy, but also a new avenue to address undruggable GPCRs.