Childhood body size directly increases type 1 diabetes risk based on a lifecourse Mendelian randomization approach

Richardson TG, Crouch DJM, Power GM,Morales-Berstein F,Hazelwood E,Fang S,Cho Y,Inshaw JRJ,Robertson CC,Sidore C,Cucca F,Rich SS, Todd JA,G Davey Smith

Yearbook of pediatric endocrinology（2022）

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摘要

Brief Summary: This Mendelian randomization study analysed genetic data from 454,023 individuals from the UK Biobank and 15,573 type 1 diabetes (T1D) cases from other cohorts and provides strong evidence that larger childhood body size increases T1D risk, independently from body size at birth and during adulthood.

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childhood body size,lifecourse mendelian randomization approach,diabetes risk

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