Embryonic osteocalcin signalling determines lifelong adrenal steroidogenesis and homeostasis in the mouse

Yadav VK, Berger JM,Singh P,Nagarajan P,Karsenty G

Yearbook of pediatric endocrinology（2022）

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摘要

Brief summary: Using rodent and primate models, this study shows a classical endocrine feedback loop, where bone-derived osteocalcin enhances adrenal steroidogenesis, and the inactivation of osteocalcin signalling impairs adrenal growth and steroidogenesis.

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lifelong adrenal steroidogenesis,embryonic osteocalcin,homeostasis

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