Metabolomic profiling reveals extensive adrenal suppression due to inhaled corticosteroid therapy in asthma

Kachroo P, Stewart ID, Kelly RS,Stav M,Mendez K,Dahlin A, Soeteman DI, Chu SH,Huang M,Cote M, Knilhtila HM,Lee-Sarwar K,McGeachie M,Wang A, Wu AC,Virkud Y,Zhang P, Wareham NJ, Karlson EW, Wheelock CE,Clish C, Weiss ST,Langenberg C, Lasky-Su JA

Yearbook of pediatric endocrinology（2022）

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摘要

Brief summary: This study performed large-scale metabolomic profiling across 14 000 adults from 4 cohorts and identified 17 steroid metabolites whose levels were reduced in individuals with prevalent asthma. The largest reductions were associated with inhaled corticosteroid (ICS) treatment, and these were validated in samples from a clinical trial of low-dose ICS.

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metabolomic profiling,asthma,corticosteroid therapy,extensive adrenal suppression

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