Metabolic syndrome in male survivors of pediatric allogeneic hematopoietic stem cell transplantation: impact of total body irradiation, low-grade inflammation, and hypogonadism

Brief Summary: Several studies in cancer survivors have reported an increased prevalence of metabolic syndrome (MetS), which is often observed in the absence of overt obesity. Data about MetS in survivors of pediatric hematopoietic stem cell transplantation (HSCT) are scarce. This cross-sectional cohort study evaluated the prevalence and clinical presentation of MetS in 98 adult male survivors of pediatric HSCT (median follow-up 18 years, 74% received total body irradiation, TBI) and 4767 male controls from the background population.