Label-free detection of SARS-CoV-2 neutralizing antibodies in human serum by Bloch surface waves on 1D photonic crystal biochips

Agostino Occhicone,Alberto Sinibaldi,Tommaso Pileri, Paola Di Matteo, Daniele Chiappetta,Peter Munzert,Norbert Danz,Frank Sonntag,Matteo Allegretti, Valentina De Pascale,Chiara Mandoj,Laura Conti,Francesco Michelotti

Frontiers in Optics + Laser Science 2022 (FIO, LS)（2022）

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摘要

We propose a rapid serologic test based on disposable nano-photonic biochips for SARS-CoV-2 related antibodies. The label-free sensograms showed that positive and negative human serum samples were discriminated, enabling real-time and fast label-free detection.

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