Correlations between Biochemical and Immunological Parameters in Volunteers under Conditions of 21-Day “Dry” Immersion

The results of studying the correlations between biochemical and immunological parameters in volunteers under conditions of 21-day “dry” immersion are presented. It is shown that, in comparison with the baseline period, at the final stage of the experiment, the number of statistically significant correlations ( p ≤ 0.05, respectively, 27 and 51) between the parameters assessing the metabolic and immunological reactions of the body increased. The increase in the number of correlations was due mainly to an increase in the number of correlations between the indices of protein, carbohydrate, and lipid metabolism and indices characterizing the state of innate immunity. At the final stage of the experiment, the influence of protein and lipid metabolism on the cellular component of adaptive immunity increased. The revealed dynamics and the nature of correlations between biochemical and immunological indices indicate the metabolic regulation of the immune response under conditions of hypodynamic support unloading.